BIOHACKING. EVOLVED. · RESEARCH SYSTEM

The Peptide Index

A living evidence map of the peptides shaping modern biohacking.

Don't start with popularity. Start with what we actually know. Compare human evidence, community attention, regulatory status and the distance between the story people tell and the evidence that exists.

How to read the Index
Research the science.
Track the community.
Separate signal from hype.

Every profile uses the same editorial framework so radically different compounds can be evaluated on the same page without pretending the evidence is equivalent.

Flagship profiles
18
Full evidence profiles live now
Strongest human evidence
TESAMORELIN
Established efficacy in a specific approved indication
Biggest evidence gaps
BPC · KPV · TB-500
Community confidence far exceeds human evidence
Fastest-moving story
RETATRUTIDE
Late-stage clinical development + intense public attention
Evidence rule
CONTEXT MATTERS
Approval and evidence belong to the molecule, population and outcome studied
01 / FLAGSHIP EVIDENCE PROFILES

Eighteen flagship profiles.

Flagship profiles provide a consistent evidence review, community context, regulatory status and an In Plain English translation.

BPC-157↗

IN PLAIN ENGLISHBPC-157 may support the body’s natural repair processes, which helps explain why the community is so interested in it for injuries, inflammation and recovery.

Human Evidence●○○○○
The GapVERY WIDE
Recovery · Gut HealthNot FDA approved
Retatrutide↗

IN PLAIN ENGLISHRetatrutide targets three metabolic hormone pathways and has produced substantial weight loss in human clinical trials.

Human Evidence●●●●○
The GapCONTEXT-DEPENDENT
Metabolic HealthInvestigational
Tirzepatide↗

IN PLAIN ENGLISHTirzepatide works on two appetite and metabolic pathways, helping many people dramatically reduce hunger while improving blood-sugar control and driving substantial weight loss.

Human Evidence●●●●●
The GapCONTEXT-DEPENDENT
Metabolic Health · Diabetes · Weight ManagementFDA approved
Glutathione↗

IN PLAIN ENGLISHGlutathione is one of the body’s primary antioxidant-defense molecules, helping cells manage oxidative stress and maintain normal detoxification and repair processes.

Human Evidence●●●○○
The GapMEANINGFUL
Oxidative Stress · Recovery · SkinRoute-dependent
Tesamorelin↗

IN PLAIN ENGLISHTesamorelin stimulates your body’s own growth-hormone pathway and has been shown in humans to reduce visceral abdominal fat in a specific clinical population.

Human Evidence●●●●●
The GapCONTEXT-DEPENDENT
Metabolic Health · GH AxisFDA approved · specific indication
MOTS-c↗

IN PLAIN ENGLISHMOTS-c may help your body manage and use energy more efficiently, especially during metabolic stress such as exercise.

Human Evidence●●○○○
The GapWIDE
Cellular Energy · Metabolic HealthNot FDA approved
KPV↗

IN PLAIN ENGLISHKPV appears to calm inflammatory signaling, which is why it’s gaining attention for gut health and broader inflammation.

Human Evidence●○○○○
The GapVERY WIDE
Gut Health · RecoveryNot FDA approved
SS-31 / Elamipretide↗

IN PLAIN ENGLISHSS-31 targets mitochondria to help them produce energy more efficiently, an approach now validated for one rare mitochondrial disease.

Human Evidence●●●●○
The GapCONTEXT-DEPENDENT
Cellular Energy · PerformanceFDA approved · specific indication
TB-500↗

IN PLAIN ENGLISHTB-500 is used in the community to support healing, mobility and recovery, based largely on promising repair biology related to thymosin beta-4.

Human Evidence●○○○○
The GapVERY WIDE
RecoveryNot FDA approved
GHK-Cu↗

IN PLAIN ENGLISHGHK-Cu supports collagen and tissue-remodeling biology, making it especially interesting for skin, hair, wound healing and recovery.

Human Evidence●●○○○
The GapWIDE
Skin · Repair · LongevityRoute-dependent
Selank↗

IN PLAIN ENGLISHSelank has shown a human signal for reducing anxiety and is increasingly used by the community to support a calmer, more focused mental state.

Human Evidence●●●○○
The GapMEANINGFUL
Cognition · AnxietyInvestigational
CJC-1295↗

IN PLAIN ENGLISHCJC-1295 stimulates your body to release more of its own growth hormone and IGF-1, which is why it has become popular for recovery, body composition and performance.

Human Evidence●●●○○
The GapMEANINGFUL
GH Axis · RecoveryInvestigational
Ipamorelin↗

IN PLAIN ENGLISHIpamorelin signals your body to release more of its own growth hormone, which is why it has become popular for recovery, body composition, sleep and performance.

Human Evidence●●●○○
The GapMEANINGFUL
GH Axis · Recovery · SleepInvestigational
Sermorelin↗

IN PLAIN ENGLISHSermorelin signals your pituitary to release more of your own growth hormone, which is why it has become popular for sleep, recovery, body composition and healthy-aging goals.

Human Evidence●●●●○
The GapCONTEXT-DEPENDENT
GH Axis · RecoveryHistorical FDA product / current context varies
Epitalon↗

IN PLAIN ENGLISHEpitalon is being studied for its effects on cellular aging signals—including telomerase and telomeres—which is why it has become one of the most talked-about peptides in longevity circles.

Human Evidence●●○○○
The GapWIDE
Longevity · Cellular AgingInvestigational
Cibinetide / ARA-290↗

IN PLAIN ENGLISHCibinetide is designed to switch on the body’s tissue-protection and repair signaling without the blood-building effects of erythropoietin, making it especially interesting for nerve damage, neuropathic symptoms and inflammation.

Human Evidence●●●●○
The GapMODERATE
Neuropathy · Tissue ProtectionInvestigational
NAD+↗

IN PLAIN ENGLISHNAD+ is essential to cellular energy biology. Human trials of NAD+ precursors exist, but evidence for direct NAD+ treatment improving longevity or performance remains limited.

Human Evidence●●○○○
The GapWIDE
Cellular Energy · LongevityRoute-dependent evidence
5-Amino-1MQ↗

IN PLAIN ENGLISH5-Amino-1MQ blocks an enzyme called NNMT; early laboratory and animal findings suggest metabolic effects, but fat-loss benefits in humans have not been established.

Human Evidence○○○○○
The GapVERY WIDE
Metabolic Health · Body CompositionNot FDA approved
02 / BLENDS

When compounds become combinations.

Blends get their own evidence treatment. We separate what is known about each component from what has actually been demonstrated about the finished combination.

Blend · Recovery

Wolverine

BPC-157 + TB-500

Two of the community’s most popular recovery peptides. One combination whose reputation has developed much faster than its direct evidence.

Combination Evidence●○○○○
The GapVERY WIDE
View Blend Evidence Profile →
Blend · Recovery + Tissue Remodeling

GLOW

GHK-Cu + BPC-157 + TB-500

Recovery meets tissue remodeling and skin biology. Three compelling component stories—without direct evidence that the blend itself delivers the combined promise.

Combination Evidence●○○○○
The GapVERY WIDE
View Blend Evidence Profile →

Blend rule: evidence for individual ingredients does not automatically become evidence for the combination. Blend profiles track component evidence, combination evidence and Community Signal separately.

03 / FULL PEPTIDE INDEX

Explore the broader library.

Explore the wider library of compounds and community blends. The eighteen flagship profiles above are our deepest evidence reviews.

45 additional Index entries
45 additional Index entries
Why two levels? Every compound stays discoverable in the Index. Deep-Dive Evidence Profiles are the entries that have completed our more intensive source review, Claim vs Evidence analysis, Community Signal comparison, Evidence Ledger and regulatory verification.
04 / WHAT THE SCORES MEAN

Evidence maturity, not a leaderboard.

A five-dot Human Evidence score does not mean “better peptide.” It means the compound has a deeper human evidence base for at least one defined use.

Human EvidenceDepth and quality of controlled human research—not online popularity.
Community SignalHow strongly the compound is being discussed, explored and reported in public communities. It is not efficacy evidence.
The GapThe distance between community claims and what controlled human evidence can actually support.
Regulatory StatusApproval applies to a specific drug, indication and population. It should not be generalized to every product using the same peptide name.
The Index is designed to make uncertainty visible, not hide it behind a single score.
05 / EDITOR'S READ

What stands out right now.

Biggest Gap

BPC-157

Recovery culture has built a remarkably confident story around a compound with only tiny, uncontrolled human datasets.

Read BPC-157 →

Most Important Collision

Retatrutide

Powerful late-stage clinical evidence is colliding with an unapproved online market. Trial efficacy and product legitimacy are separate questions.

Read Retatrutide →

Evidence Lesson

TB-500

Related molecules cannot simply inherit one another's clinical evidence. TB-500 and full-length thymosin beta-4 make that distinction unusually clear.

Read TB-500 →

Category Shift

SS-31 / Elamipretide

One of the rare peptide stories to cross from experimental research into an FDA-approved medicine—while retaining a much broader biohacking reputation.

Read SS-31 →

06 / START WITH THE OUTCOME

The compound isn't the question. The outcome is.

The Peptide Index is one way into the science. Outcome Hubs reverse the lens: begin with recovery, metabolic health, cognition, gut health or longevity, then ask which interventions actually have evidence.

Explore Outcome Hubs →

Editorial note: BIOHACKING. EVOLVED. is an educational publication, not a medical provider. The Peptide Index does not provide dosing, sourcing, treatment or prescribing guidance. Evidence ratings are editorial orientation and should be read alongside each profile's underlying studies, limitations and regulatory context.