The Peptide Index — Evidence, Community Signal & Regulatory Status | BIOHACKING. EVOLVED.
BIOHACKING. EVOLVED. · RESEARCH SYSTEM

The Peptide Index

A living evidence map of the peptides shaping modern biohacking.

Don't start with popularity. Start with what we actually know. Compare human evidence, community attention, regulatory status and the distance between the story people tell and the evidence that exists.

How to read the Index
Research the science.
Track the community.
Separate signal from hype.

Every profile uses the same editorial framework so radically different compounds can be evaluated on the same page without pretending the evidence is equivalent.

Flagship profiles
7
Source-backed deep dives live now
Strongest human evidence
TESAMORELIN
Established efficacy in a specific approved indication
Biggest evidence gaps
BPC · KPV · TB-500
Community confidence far exceeds human evidence
Fastest-moving story
RETATRUTIDE
Late-stage clinical development + intense public attention
Evidence rule
CONTEXT MATTERS
Approval and evidence belong to the molecule, population and outcome studied
01 / DEEP-DIVE EVIDENCE PROFILES

Seven flagship profiles.

Our fully researched, source-backed deep dives. Compare Human Evidence, Community Signal, The Gap, outcome and regulatory status using one consistent editorial framework.

BPC-157

Recovery's most talked-about peptide—and one of its biggest evidence gaps.

Promising biology. Unproven therapy.
Human Evidence●○○○○
Community Signal●●●●●
The GapVERY WIDE
Recovery · Gut HealthNot FDA approved
Retatrutide

A triple-agonist obesity medicine with unusually strong clinical weight-loss data.

Strong clinical signal. Still investigational.
Human Evidence●●●●○
Community Signal●●●●●
The GapCONTEXT-DEPENDENT
Metabolic HealthInvestigational
Tesamorelin

Real approval and strong human evidence—with an indication narrower than its biohacking reputation.

Established efficacy. Specific indication.
Human Evidence●●●●●
Community Signal●●●●○
The GapCONTEXT-DEPENDENT
Metabolic HealthFDA approved · specific indication
MOTS-c

An endogenous mitochondrial signal whose biology is more established than its therapeutic use.

Compelling biology. Human therapy unproven.
Human Evidence●●○○○
Community Signal●●●●○
The GapWIDE
Cellular Energy · Metabolic HealthNot FDA approved
KPV

A tiny anti-inflammatory peptide with a broad preclinical story and almost no human therapeutic evidence.

Interesting anti-inflammatory signal. Human efficacy unproven.
Human Evidence●○○○○
Community Signal●●●●○
The GapVERY WIDE
Gut Health · RecoveryNot FDA approved
SS-31 / Elamipretide

A mitochondria-targeting peptide that became an FDA-approved medicine for Barth syndrome.

Real human evidence. Real approval. Narrow indication.
Human Evidence●●●●○
Community Signal●●●●○
The GapCONTEXT-DEPENDENT
Cellular Energy · PerformanceFDA approved · specific indication
TB-500

A recovery-culture staple whose reputation frequently borrows evidence from full-length thymosin beta-4.

Biologically related. Clinically not equivalent.
Human Evidence●○○○○
Community Signal●●●●●
The GapVERY WIDE
RecoveryNot FDA approved
02 / FULL PEPTIDE INDEX

Explore the broader library.

51 peptides tracked. The seven flagship profiles above are our deepest evidence reviews. The additional 44 entries remain available while we progressively upgrade them into full Evidence Profiles.

44 additional Index entries
44 additional Index entries
Why two levels? Every compound stays discoverable in the Index. Deep-Dive Evidence Profiles are the entries that have completed our more intensive source review, Claim vs Evidence analysis, Community Signal comparison, Evidence Ledger and regulatory verification.
03 / WHAT THE SCORES MEAN

Evidence maturity, not a leaderboard.

A five-dot Human Evidence score does not mean “better peptide.” It means the compound has a deeper human evidence base for at least one defined use.

Human EvidenceDepth and quality of controlled human research—not online popularity.
Community SignalHow strongly the compound is being discussed, explored and reported in public communities. It is not efficacy evidence.
The GapThe distance between community claims and what controlled human evidence can actually support.
Regulatory StatusApproval applies to a specific drug, indication and population. It should not be generalized to every product using the same peptide name.
The Index is designed to make uncertainty visible, not hide it behind a single score.
04 / EDITOR'S READ

What stands out right now.

Biggest Gap

BPC-157

Recovery culture has built a remarkably confident story around a compound with only tiny, uncontrolled human datasets.

Read BPC-157 →

Most Important Collision

Retatrutide

Powerful late-stage clinical evidence is colliding with an unapproved online market. Trial efficacy and product legitimacy are separate questions.

Read Retatrutide →

Evidence Lesson

TB-500

Related molecules cannot simply inherit one another's clinical evidence. TB-500 and full-length thymosin beta-4 make that distinction unusually clear.

Read TB-500 →

Category Shift

SS-31 / Elamipretide

One of the rare peptide stories to cross from experimental research into an FDA-approved medicine—while retaining a much broader biohacking reputation.

Read SS-31 →

05 / START WITH THE OUTCOME

The compound isn't the question. The outcome is.

The Peptide Index is one way into the science. Outcome Hubs reverse the lens: begin with recovery, metabolic health, cognition, gut health or longevity, then ask which interventions actually have evidence.

Explore Outcome Hubs →

Editorial note: BIOHACKING. EVOLVED. is an educational publication, not a medical provider. The Peptide Index does not provide dosing, sourcing, treatment or prescribing guidance. Evidence ratings are editorial orientation and should be read alongside each profile's underlying studies, limitations and regulatory context.